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474 16 Nanostructured Biosensing and Biochips for DNA Analysis thiolated primers and blocking agent (6-mercaptohexanol) on the gold surface resulted in significant changes in the refractive index of the layer medium and therefore could be detected by the increment in the RRI of the nanostructured surface spectra. This shift is signaled by the fact that an experiment about the learning of a geometrical theorem is chosen to support the doctrine of recollection, for Plato's deep interest in mathematics is evident throughout the middle and late dialogues, but is not yet present in his early works.

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